ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters 发表药物化学相关领域研究方向的稿件。该期刊涉及广泛的研究领域，包括化合物设计和优化、生物评估、药物递送、显像剂以及生物活性分子（小分子和大分子）药理学。ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)Biological characterization of new molecular entities in the context of drug discoveryComputational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistryDiscovery technologies for biologically active molecules from both synthetic and natural (plant and other) sourcesPharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and responsePharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinicMechanistic drug metabolism and regulation of metabolic enzyme gene expressionChemistry patents relevant to the medicinal chemistry field